Speaker Profile

PHARMD, M.D., Director, Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Department of Pediatrics, Children’s Mercy Hospital, Kansas City, MO

As Director of the Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation at Children’s Mercy Kansas City, Dr. Leeder leads a group of clinicians and researchers committed to implementing precision therapeutics to improve the treatment of pediatric disease. His research focuses on characterizing the relative contributions of ontogeny and genetic variation to observed variability in drug response in children, and these efforts have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids, one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development. Dr. Leeder holds the Marion Merrell Dow/Missouri Endowed Chair in Pediatric Clinical Pharmacology and serves Deputy Director of the Children’s Research Institute at CMH. He received his education and training at the University of Minnesota (PharmD) and University of Toronto (PhD).


Precision Therapeutics for Children: The GOLDILOKs Initiative
This presentation will raise awareness of the extent of variability in the dose-exposure relationship in children, its implications for addressing variability in therapeutic response, and present the Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids (GOLDILOKs) initiative as a strategy to implement precision therapeutics in children.

Session Abstract – PMWC 2018 Michigan

Session Synopsis: Using pharmacogenomic data within the clinic is quickly becoming the standard of care for certain medication-gene pairs; and as research in pharmacogenomics continues to evolve, this data needs to be readily translated into clinic. Therefore, this session will outline some of this research and identify novel evidence based approaches being used to improve overall patient outcomes.

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