Speaker Profile

M.D., Ph.D, M.P.H, Director, USC Norris Comprehensive Cancer Center; Professor of Medicine & Preventive Medicine; Jane & Kris Popovich Chair in Cancer Research

Stephen B. Gruber, M.D., Ph.D., M.P.H., Director of the USC Norris Comprehensive Cancer Center, is a Professor of Medicine at the Keck School of Medicine of the University of Southern California, and the H. Leslie Hoffman and Elaine S. Hoffman Chair in Cancer Research. Dr. Gruber is a board certified medical oncologist, cancer geneticist and epidemiologist whose research focuses on genetic and environmental contributions to cancer. His particular research interests include the genetic epidemiology of cancer, with emphasis on colorectal cancer; the molecular pathogenesis of cancer, integrated with genetic epidemiology; methods in genetic and molecular epidemiology; and clinical cancer genetics and translational research in cancer prevention. The goal of his research is to find new ways to prevent cancer and to improve treatment and care for cancer patients. He has received a variety of honors and awards and is the author of 158 peer-reviewed publications, many in very high quality journals attesting to his standing in the field of cancer genetics, particularly as it relates to colorectal cancer. In addition to serving on editorial boards for several professional journals, Dr. Gruber is active in national organizations. Since 2005, he has been chair of the Colorectal Family Registries Advisory Panel for the National Cancer Institute and for the past three years chaired the Cancer Genetics Education Committee of the American Society of Clinical Oncology.


Genomic Profiling Showcase: Precision Oncology – ORIEN Consortium to Patient Care
The challenges of converting research genomic profiling to clinically actionable recommendations for patients requires a multidisciplinary approach integrating medical oncology, medical genetics, genetic counseling, bioinformatics, pathology, and CLIA-laboratories in a timely manner. The Oncology Research Information Exchange Network (ORIEN) connects patients with clinical trials based on their molecular profile through a lifetime partnership with patients. ORIEN provides the information and tools needed to study the long-term effects of disease, while providing a framework for cancer center member institutions to prospectively identify patients for discovery research and anticipatory clinical trial eligibility. Examples from the USC Norris Comprehensive Cancer Center will highlight the value of collaborative science through ORIEN.

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