Speaker Profile
M.D., Warner-Lambert/Parke-Davis Professor of Internal Medicine/Nephrology and Computational Medicine and Bioinformatics at the University of Michigan Medical School
Biography
Dr. Kretzler is the Warner-Lambert/Parke-Davis Professor of Internal Medicine/Nephrology and Computational Medicine and Bioinformatics. The overarching goal of his research is to define chronic organ dysfunction in mechanistic terms and use this knowledge for targeted therapeutic interventions. To reach this goal he has developed a translational research pipeline centered on integrated systems biology analysis of renal disease. He leads the U54 Nephrotic Syndrome Research Network (Neptune) in the Rare Disease Clinical Research Network II, the Coordinating center of the CureGN research network, is the Director of the Applied Systems Biology Core, principle investigator in the R24 “Integrated Systems Biology Approach to Diabetic Microvascular Complications” and in the NIH Acceleration of Medicine (AMP) program in autoimmunity. He has 20 years of experience in integration of bioinformatics, molecular and clinical approaches in more than 230 papers and holds patents for diagnostic and therapeutics of chronic renal disease. He has a tract record on interdisciplinary data integration of large-scale data sets in international multi-disciplinary research networks in the US, Europe, China and sub-Saharan Africa. These studies enable precision medicine across the genotype-phenotype continuum using carefully monitored environmental exposures, genetic predispositions, epigenetic markers, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histological biopsy archive and prospective clinical disease characterization. The molecular mechanism identified have result in new disease predictors and the first successful clinical trials of a novel therapeutic modality in glomerular diseases.
Talk
Defining Renal Disease Across Disciplines and Continents
The presentation will introduce research strategies is to define kidney disease in mechanistic terms in international multi-disciplinary research networks in the US, Europe, China and sub-Saharan Africa. Precision medicine is enabled across the genotype-phenotype continuum using carefully monitored environmental exposures, genetic predispositions, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histology and prospective clinical disease characterization leading to new disease predictors and successful clinical trials.
